PNC27 is a synthetic, chimeric peptide consisting of a p53-derived HDM-2 binding domain linked to a cell-penetrating peptide (CPP) leader sequence. It is the subject of research for its mechanism of action, which is proposed to involve selective binding to HDM-2 (MDM2) proteins expressed on the plasma membranes of certain cell types.

This binding is theorized to induce the formation of transmembrane pores, leading to cell lysis (necrosis). Unlike many peptides that target internal cellular pathways, PNC27 is noted for this direct action on the cell membrane. This product is provided as a lyophilized powder intended strictly for in-vitro laboratory research and development.

• CAS Number: 1159861-00-3

• Appearance: White Lyophilized Powder

• Amount: 10mg

• Purity: >98% (as determined by HPLC)

• Sequence: H-Pro-Pro-Leu-Ser-Gln-Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly-OH

• Storage: Store at -20°C.

This product is sold for research and laboratory use only. Not for human consumption or therapeutic use.