Overview

CJC-1295 without DAC is a sophisticated, 29-amino acid synthetic peptide designed as a stabilized analogue of endogenous Growth Hormone-Releasing Hormone (GHRH). In biochemical literature, it is frequently identified as Modified GRF (1-29).

The “Modified” nomenclature signifies a precision-engineered sequence featuring four strategic amino acid substitutions. These modifications are specifically designed to inhibit rapid enzymatic cleavage by dipeptidyl peptidase-IV (DPP-IV), significantly enhancing the peptide’s metabolic stability and biological half-life compared to the native GHRH molecule.

Mechanism of Action

As a potent GHRH agonist, Modified GRF (1-29) targets the GHRH receptors located within the somatotroph cells of the anterior pituitary gland. Upon binding, it initiates a signaling cascade that stimulates the synthesis and secretion of endogenous Growth Hormone (GH).

The “Without DAC” Distinction

The primary differentiator of this formulation is the absence of the Drug Affinity Complex (DAC). This exclusion is critical for specific research objectives:

• Pharmacokinetic Precision: Without the albumin-binding DAC, this peptide maintains a transient active half-life of approximately 30 minutes.

• Pulsatile Secretion Mimicry: This rapid clearance profile allows researchers to simulate the body’s natural pulsatile (wave-like) secretion of GH. This “spike and clear” rhythm avoids the sustained “GH bleed” associated with longer-acting analogues, preserving the physiological feedback loops often studied in endocrine research.

Technical Specifications

Storage & Reconstitution

To preserve molecular structural integrity:

• Refrigerated Storage: 2°C to 8°C (Ideal for active research phases).

• Long-Term Cryogenic Storage: -20°C (Recommended to prevent deamidation).

• Reconstitution: Requires a sterile diluent, such as Bacteriostatic Water, prior to laboratory application.

Regulatory Compliance & Disclaimer

LABORATORY RESEARCH ONLY: This product is synthesized strictly for in vitro laboratory analysis and scientific investigation. It is not intended for human or veterinary use, medical diagnosis, or therapeutic application. All handling must be performed by qualified professionals in accordance with established safety protocols.