CJC-1295 (Modified GRF 1-29)

High-Purity Research Peptide

Product Profile

• SKU Name: CJC-1295 without DAC

• Molecular Formula: Modified GRF (1-29)

• Quantity: 5mg

• Form: Lyophilized (Freeze-Dried) Powder

• CAS Number: 863288-34-0

Overview – 

CJC-1295 without DAC is a synthetic, 29-amino acid peptide analogue of the naturally occurring Growth Hormone-Releasing Hormone (GHRH). It is frequently referred to as Modified GRF (1-29) due to its specific structural engineering.

To enhance metabolic stability, this analogue incorporates four key amino acid substitutions (at positions 2, 8, 15, and 27). These modifications are designed to shield the peptide from rapid enzymatic cleavage by dipeptidyl peptidase-IV (DPP-IV), resulting in a significantly more resilient compound compared to native GHRH while maintaining high biological activity.

Mechanism of Action

As a potent GHRH secretagogue, Modified GRF (1-29) targets and binds to the GHRH receptors located on the somatotroph cells of the anterior pituitary. This signaling cascade triggers the synthesis and subsequent secretion of endogenous Growth Hormone (GH) into the bloodstream.

The “Without DAC” Distinction

This formulation specifically excludes the Drug Affinity Complex (DAC), which radically alters its pharmacokinetic profile:

• Pulsatile Secretion: By maintaining a short half-life (approximately 30 minutes), this version allows for physiological-style pulsatile GH release, mimicking natural biological rhythms.

• Rapid Clearance: Unlike the DAC-variant—which binds to albumin for a prolonged “bleed” of growth hormone—the non-DAC version is cleared quickly, offering researchers more precise control over the timing of GH elevations.

Technical Specifications

Important Safety Information

Research Use Only: This product is strictly for laboratory research and analytical purposes. It is not intended for human or veterinary consumption, nor for therapeutic or diagnostic use. Ensure all handling is performed by qualified professionals using appropriate safety protocols.