Executive Overview

SELANK is a high-purity synthetic neuropeptide engineered by the Institute of Molecular Genetics of the Russian Academy of Sciences. It is a metabolic-stable analogue of the endogenous immunomodulatory peptide Tuftsin ($Thr$–$Lys$–$Pro$–$Arg$). By extending the natural Tuftsin sequence with a $Pro$–$Gly$–$Pro$ tripeptide fragment, researchers created a heptapeptide with significantly enhanced enzymatic resistance and biological persistence.

Pharmacological Profile & Mechanisms

SELANK is primarily investigated for its multifaceted impact on the central nervous system, acting as both a potent anxiolytic and a cognitive enhancer (nootropic).

1. GABAergic Modulation

In research models, SELANK demonstrates the ability to allosterically modulate GABA-A receptors. While its effects are comparable to traditional anxiolytics, studies suggest a unique profile that lacks the typical sedative, amnesic, or addictive characteristics of benzodiazepines.

2. Neurotrophic & Monoamine Influence

SELANK facilitates neuroplasticity and cognitive resilience through two primary pathways:

• BDNF Elevation: It rapidly increases the expression of Brain-Derived Neurotrophic Factor (BDNF), a critical protein for neuronal survival, synaptic growth, and long-term potentiation (memory formation).

• Neurotransmitter Regulation: It modulates the concentrations of monoamine neurotransmitters, specifically Serotonin and Dopamine, to assist in mood stabilization and focus under physiological stress.

3. Immunomodulatory Heritage

Retaining its ancestral link to Tuftsin, SELANK is researched for its influence on the immune system, specifically its ability to modulate cytokine expression and reinforce the body’s natural defensive responses during environmental or psychological stressors.

Chemical & Physical Specifications

Storage & Research Handling

• Container: 5mg vacuum-sealed sterile vial.

• Storage (Lyophilized): Store at -20°C for long-term stability.

• Storage (Reconstituted): Once dissolved in a suitable research solvent (e.g., Bacteriostatic Water), store at 2°C to 8°C.

• Integrity: Avoid excessive agitation and protect from direct UV light to prevent peptide bond degradation.

Institutional Research Disclaimer

WARNING: This product is synthesized and distributed strictly for in-vitro laboratory research and development purposes only. It is not intended for human or veterinary consumption, medical diagnosis, or therapeutic application. The purchase of this product constitutes an agreement to follow all institutional safety protocols for handling synthetic neuropeptides.