Precision ACTH (4-10) Analogue | Advanced Neurogenic Research Peptide

Executive Overview

SEMAX is a high-performance synthetic heptapeptide with the primary sequence Met-Glu-His-Phe-Pro-Gly-Pro. It was engineered as a metabolic-stable analogue of a fragment of the Adrenocorticotropic Hormone (ACTH). While derived from ACTH, SEMAX is specifically designed to be non-hormonal, meaning it does not stimulate the adrenal cortex or influence systemic cortisol levels.

Instead, it functions as a highly targeted neuropeptide, exerting profound influence over the central nervous system (CNS). It is widely regarded in research for its dual-action profile as both a potent nootropic and a robust neuroprotective agent.

Mechanism of Action

The biological activity of SEMAX is multifaceted, focusing on the preservation and optimization of neural pathways:

1. The BDNF/TrkB Pathway

The most significant researched function of SEMAX is its ability to rapidly upregulate Brain-Derived Neurotrophic Factor (BDNF) and its high-affinity receptor, TrkB.

• Neurogenesis: Supports the differentiation of new neurons.

• Synaptic Plasticity: Strengthens the connections (synapses) between neurons, which is the foundational mechanism for memory consolidation and learning.

• Neuronal Survival: Protects existing neural structures from degradation.

2. Neurotransmitter Regulation

SEMAX modulates the brain’s dopaminergic and serotonergic systems. By stabilizing the levels of these monoamines, it is researched for its ability to enhance executive function, maintain focus, and regulate mood under physiological or psychological stress.

3. Blood-Brain Barrier (BBB) Permeability

Due to its peptide structure, SEMAX has low oral bioavailability. Research protocols typically utilize intranasal delivery to bypass the digestive tract and cross the blood-brain barrier via the olfactory and trigeminal nerve pathways, allowing for direct interaction with the CNS.

Primary Research Domains

Technical Specifications

• Product Name: SEMAX

• CAS Number: 80714-61-0

• Molecular Sequence: $Met$–$Glu$–$His$–$Phe$–$Pro$–$Gly$–$Pro$

• Quantity: 5 mg

• Purity: ≥98.0% (HPLC Validated)

• Physical State: Sterile, white lyophilized (freeze-dried) powder

Storage & Handling Protocols

To maintain the structural integrity of the heptapeptide:

• Lyophilized Powder: Store at -20°C for long-term stability.

• Reconstituted Solution: Once mixed with a suitable diluent (e.g., Bacteriostatic Water), store at 2°C to 8°C.

• Integrity: Protect from direct sunlight and avoid vigorous agitation of the vial.

Strict Research Disclaimer

FOR RESEARCH USE ONLY: This compound is intended exclusively for in vitro laboratory analysis and scientific research. It is not intended for human or veterinary consumption, medical diagnosis, or therapeutic use. All information provided is for educational purposes.